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HaijunWTingtingLDongxiaoLQiWZhiPengJHongZet alA case of glutathione synthetase deficiency caused by GSS gene mutations

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304 In MASH patients, ferroptosis-related genes like SLC40A1, ACSL5, CP, and SLC11A2 are downregulated, while ACSL4, ACSL6, ferritin light chain (FTL), and FTH1 are upregulated

231,250 Besides, from the perspective of modification mechanisms, both lactylation and acetylation preferred targeting lysine (Lys) residues for epigenetic modulation, which utilized p300 as the writer for Lys catalysis and class I-III histone deacetylases (HDAC1-3) as eraser